1G8L

CRYSTAL STRUCTURE OF ESCHERICHIA COLI MOEA

1G8L の概要

• エントリーDOI: 10.2210/pdb1g8l/pdb
• 関連するPDBエントリー: 1G8R
• 分子名称: MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN, GLYCEROL (3 entities in total)
• 機能のキーワード: molybdenum cofactor biosynthesis, metal binding protein
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89869.81

構造登録者

Xiang, S.,Nichols, J.,Rajagopalan, K.V.,Schindelin, H. (登録日: 2000-11-17, 公開日: 2001-05-02, 最終更新日: 2024-02-07)

主引用文献

Xiang, S.,Nichols, J.,Rajagopalan, K.V.,Schindelin, H.
The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
Structure, 9:299-310, 2001

PubMed Abstract: Molybdenum cofactor (Moco) biosynthesis is an evolutionarily conserved pathway present in archaea, eubacteria, and eukaryotes. In humans, genetic abnormalities in the biosynthetic pathway result in Moco deficiency, which is accompanied by severe neurological symptoms and death shortly after birth. The Escherichia coli MoeA and MogA proteins are involved in the final step of Moco biosynthesis: the incorporation of molybdenum into molybdopterin (MPT), the organic pyranopterin moiety of Moco.

PubMed: 11525167
DOI: 10.1016/S0969-2126(01)00588-3

実験手法

X-RAY DIFFRACTION (1.95 Å)