1G6R

A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX

1G6R の概要

• エントリーDOI: 10.2210/pdb1g6r/pdb
• 関連するPDBエントリー: 2CKB
• 分子名称: ALPHA T CELL RECEPTOR, BETA T CELL RECEPTOR, MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULE, ... (5 entities in total)
• 機能のキーワード: t cell antigen receptor, major histocompatibility complex, superagonist, immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Membrane ; Single-pass membrane protein : P01852; Membrane; Single-pass type I membrane protein: P01901; Secreted: P01887
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 185941.85

構造登録者

Degano, M.,Garcia, K.C.,Apostolopoulos, V.,Rudolph, M.G.,Teyton, L.,Wilson, I.A. (登録日: 2000-11-07, 公開日: 2000-11-15, 最終更新日: 2024-11-13)

主引用文献

Degano, M.,Garcia, K.C.,Apostolopoulos, V.,Rudolph, M.G.,Teyton, L.,Wilson, I.A.
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.
Immunity, 12:251-261, 2000

PubMed Abstract: A longstanding question in T cell receptor signaling is how structurally similar ligands, with similar affinities, can have substantially different biological activity. The crystal structure of the 2C TCR complex of H-2Kb with superagonist peptide SIYR at 2.8 A elucidates a structural basis for TCR discrimination of altered peptide ligands. The difference in antigen potency is modulated by two cavities in the TCR combining site, formed mainly by CDRs 3alpha, 3beta, and 1beta, that complement centrally located peptide residues. This "functional hot spot" allows the TCR to finely discriminate amongst energetically similar interactions within different ligands for those in which the peptide appropriately stabilizes the TCR/pMHC complex and provides a new structural perspective for understanding differential signaling resulting from T cell cross-reactivity.

PubMed: 10755612
DOI: 10.1016/S1074-7613(00)80178-8

実験手法

X-RAY DIFFRACTION (2.8 Å)