1G65
Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors
Summary for 1G65
Entry DOI | 10.2210/pdb1g65/pdb |
Related | 1G0U 1PMA 1RYP |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (17 entities in total) |
Functional Keywords | proteasome, epoxomicin, ubiquitin, ntn-hydolase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 30 |
Total formula weight | 705534.79 |
Authors | Groll, M.,Kim, K.B.,Kairies, N.,Huber, R.,Crews, C. (deposition date: 2000-11-03, release date: 2000-11-27, Last modification date: 2023-11-15) |
Primary citation | Groll, M.,Kim, K.B.,Kairies, N.,Crews, C. Crystal Structure of Epoxomicin:20S Proteasome reveals a molecular basis for selectivity of alpha,beta-Epoxyketone Proteasome Inhibitors J.Am.Chem.Soc., 122:1237-1238, 2000 Cited by DOI: 10.1021/ja993588mPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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