1G5N

ANNEXIN V COMPLEX WITH HEPARIN OLIGOSACCHARIDES

1G5N の概要

• エントリーDOI: 10.2210/pdb1g5n/pdb
• 分子名称: ANNEXIN V, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: helix-bundle, membrane binding, heparin, heparan sulfate, blood clotting
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38327.85

構造登録者

Capila, I.,Heraiz, M.J.,Mo, Y.D.,Mealy, T.R.,Campos, B.,Dedman, J.R.,Linhardt, R.J.,Seaton, B.A. (登録日: 2000-11-01, 公開日: 2001-06-06, 最終更新日: 2024-04-03)

主引用文献

Capila, I.,Hernaiz, M.J.,Mo, Y.D.,Mealy, T.R.,Campos, B.,Dedman, J.R.,Linhardt, R.J.,Seaton, B.A.
Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces.
Structure, 9:57-64, 2001

PubMed Abstract: Annexin V, an abundant anticoagulant protein, has been proposed to exert its effects by self-assembling into highly ordered arrays on phospholipid membranes to form a protective anti-thrombotic shield at the cell surface. The protein exhibits very high-affinity calcium-dependent interactions with acidic phospholipid membranes, as well as specific binding to glycosaminoglycans (GAGs) such as heparin and heparan sulfate, a major component of cell surface proteoglycans. At present, there is no structural information to elucidate this interaction or the role it may play in annexin V function at the cell surface.

PubMed: 11342135
DOI: 10.1016/S0969-2126(00)00549-9

実験手法

X-RAY DIFFRACTION (1.9 Å)