1G2D

STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (CLONE #2)

Summary for 1G2D

• Entry DOI: 10.2210/pdb1g2d/pdb
• Related: 1AAY 1G2F
• Descriptor: 5'-D(*GP*AP*CP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*AP*G)-3', 5'-D(*TP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*GP*TP*CP*C)-3', TATA BOX ZINC FINGER PROTEIN, ... (5 entities in total)
• Functional Keywords: phage display, zinc finger-dna complex, tata box, cys2his2, transcription-dna complex, transcription/dna
• Biological source: Mus musculus (house mouse)
• Cellular location: Nucleus : P08046
• Total number of polymer chains: 6
• Total formula weight: 41409.90

Authors

Wolfe, S.A.,Grant, R.A.,Elrod-Erickson, M.,Pabo, C.O. (deposition date: 2000-10-18, release date: 2001-09-07, Last modification date: 2024-04-03)

Primary citation

Wolfe, S.A.,Grant, R.A.,Elrod-Erickson, M.,Pabo, C.O.
Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes.
Structure, 9:717-723, 2001

PubMed Abstract: Several methods have been developed for creating Cys2His2 zinc finger proteins that recognize novel DNA sequences, and these proteins may have important applications in biological research and gene therapy. In spite of this progress with design/selection methodology, fundamental questions remain about the principles that govern DNA recognition. One hypothesis suggests that recognition can be described by a simple set of rules--essentially a "recognition code"--but careful assessment of this proposal has been difficult because there have been few structural studies of selected zinc finger proteins.

PubMed: 11587646
DOI: 10.1016/S0969-2126(01)00632-3

Experimental method

X-RAY DIFFRACTION (2.2 Å)