1G1G
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A MONO-PHOSPHORYLATED PEPTIDE (ETDY(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Summary for 1G1G
Entry DOI | 10.2210/pdb1g1g/pdb |
Descriptor | PROTEIN TYROSINE PHOSPHATASE 1B, MONO-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE (3 entities in total) |
Functional Keywords | hydrolase (phosphorylation), tyrosine phosphatase, peptide complex, hydrolase, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 2 |
Total formula weight | 36271.18 |
Authors | Salmeen, A.,Andersen, J.N.,Myers, M.P.,Tonks, N.K.,Barford, D. (deposition date: 2000-10-11, release date: 2001-01-17, Last modification date: 2021-11-03) |
Primary citation | Salmeen, A.,Andersen, J.N.,Myers, M.P.,Tonks, N.K.,Barford, D. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol.Cell, 6:1401-1412, 2000 Cited by PubMed: 11163213DOI: 10.1016/S1097-2765(00)00137-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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