1G0X

CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF LIR-1 (ILT2)

1G0X の概要

• エントリーDOI: 10.2210/pdb1g0x/pdb
• 分子名称: LEUCOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR-1 (2 entities in total)
• 機能のキーワード: immunoglobulin fold, 3-10 helix, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q8NHL6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21998.65

構造登録者

Chapman, T.L.,Heikema, A.P.,West Jr., A.P.,Bjorkman, P.J. (登録日: 2000-10-09, 公開日: 2001-01-17, 最終更新日: 2024-11-06)

主引用文献

Chapman, T.L.,Heikema, A.P.,West Jr., A.P.,Bjorkman, P.J.
Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2).
Immunity, 13:727-736, 2000

PubMed Abstract: LIR-1 is an inhibitory receptor that recognizes class I MHC molecules and the human cytomegalovirus class I homolog UL18. Here, we report the 2.1 A resolution crystal structure of the ligand binding portion of LIR-1 (domains 1 and 2 [D1D2]) and localize the binding region for UL18. LIR-1 D1D2 is composed of two immunoglobulin-like domains arranged at an acute angle to form a bent structure resembling the structures of natural killer inhibitory receptors (KIRs). The LIR-1 binding site comprises a portion of D1 distant from the interdomain hinge region that constitutes the KIR binding site, consistent with differences in LIR-1 and KIR recognition properties and functions.

PubMed: 11114384
DOI: 10.1016/S1074-7613(00)00071-6

実験手法

X-RAY DIFFRACTION (2.1 Å)