1FZB

CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D

1FZB の概要

• エントリーDOI: 10.2210/pdb1fzb/pdb
• 分子名称: FIBRINOGEN, PEPTIDE LIGAND GPRG, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: blood coagulation, plasma, platelet, fibrinogen, fibrin
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 169696.02

構造登録者

Spraggon, G.,Everse, S.J.,Doolittle, R.F. (登録日: 1997-08-05, 公開日: 1997-12-03, 最終更新日: 2024-10-30)

主引用文献

Spraggon, G.,Everse, S.J.,Doolittle, R.F.
Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.
Nature, 389:455-462, 1997

PubMed Abstract: In blood coagulation, units of the protein fibrinogen pack together to form a fibrin clot, but a crystal structure for fibrinogen is needed to understand how this is achieved. The structure of a core fragment (fragment D) from human fibrinogen has now been determined to 2.9 A resolution. The 86K three-chained structure consists of a coiled-coil region and two homologous globular entitles oriented at approximately 130 degrees to each other. Additionally, the covalently bound dimer of fragment D, known as 'double-D', was isolated from human fibrin, crystallized in the presence of a Gly-Pro-Arg-Pro-amide peptide ligand, which simulates the donor polymerization site, and its structure solved by molecular replacement with the model of fragment D.

PubMed: 9333233
DOI: 10.1038/38947

実験手法

X-RAY DIFFRACTION (2.9 Å)