1FYW

CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2

Summary for 1FYW

DescriptorTOLL-LIKE RECEPTOR 2 (1 entity in total)
Functional Keywordsbeta-alpha-beta fold parallel beta sheet, structural genomics, psi, protein structure initiative, northeast structural genomics consortium, nesg, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane ; Single-pass type I membrane protein  O60603
Total number of polymer chains1
Total molecular weight18455.2
Authors
Xu, Y.,Tao, X.,Shen, B.,Horng, T.,Medzhitov, R.,Manley, J.L.,Tong, L.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2000-10-03, release date: 2000-11-22, Last modification date: 2018-01-31)
Primary citation
Xu, Y.,Tao, X.,Shen, B.,Horng, T.,Medzhitov, R.,Manley, J.L.,Tong, L.
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Nature, 408:111-115, 2000
PubMed: 11081518 (PDB entries with the same primary citation)
DOI: 10.1038/35047056
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers297.7%5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution