1FYR

DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX

1FYR の概要

• エントリーDOI: 10.2210/pdb1fyr/pdb
• 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, HEPATOCYTE GROWTH FACTOR RECEPTOR PEPTIDE (3 entities in total)
• 機能のキーワード: grb2, sh2 domain, phosphopeptide, met, domain swapping, dimerization, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Golgi apparatus (By similarity): P29354; Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 55522.44

構造登録者

Schiering, N.,Casale, E.,Caccia, P.,Giordano, P.,Battistini, C. (登録日: 2000-10-03, 公開日: 2000-12-06, 最終更新日: 2023-11-15)

• 主引用文献: Schiering, N.,Casale, E.,Caccia, P.,Giordano, P.,Battistini, C.; Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.; Biochemistry, 39:13376-13382, 2000; PubMed: 11063574; DOI: 10.1021/bi0012336

実験手法

X-RAY DIFFRACTION (2.4 Å)