1FYN

PHOSPHOTRANSFERASE

1FYN の概要

• エントリーDOI: 10.2210/pdb1fyn/pdb
• 分子名称: PHOSPHOTRANSFERASE FYN, 3BP-2 (3 entities in total)
• 機能のキーワード: proto-oncogene, transferase, tyrosine-protein kinase, phosphorylation, atp-binding, myristylation, sh3 domain, complex (phosphotransferase-peptide)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane: P06241
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7984.69

構造登録者

Musacchio, A.,Saraste, M.,Wilmanns, M. (登録日: 1995-05-17, 公開日: 1996-11-08, 最終更新日: 2024-02-07)

主引用文献

Musacchio, A.,Saraste, M.,Wilmanns, M.
High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Nat.Struct.Biol., 1:546-551, 1994

PubMed Abstract: Src-homology 3 (SH3) domains bind to proline-rich motifs in target proteins. We have determined high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2. The X-ray data show that the basic mode of binding of both proline-rich peptides is the same. Peptides are bound over their entire length and interact with three major sites on the SH3 molecules by both hydrogen-bonding and van der Waals contacts. Residues 4-10 of the peptide adopt the conformation of a left-handed polyproline helix type II. Binding of the proline at position 2 requires a kink at the non-proline position 3.

PubMed: 7664083
DOI: 10.1038/nsb0894-546

実験手法

X-RAY DIFFRACTION (2.3 Å)