1FXS

GDP-FUCOSE SYNTHETASE FROM ESCHERICHIA COLI COMPLEX WITH NADP

1FXS の概要

• エントリーDOI: 10.2210/pdb1fxs/pdb
• 関連するPDBエントリー: 1BSV
• 分子名称: PROTEIN (GDP-FUCOSE SYNTHETASE), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• 機能のキーワード: epimerase-reductase, nadp, gdp-fucose, fucose synthetase, oxidoreductase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P32055
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36930.51

構造登録者

Somers, W.S.,Stahl, M.L.,Sullivan, F.X. (登録日: 1998-09-01, 公開日: 1999-08-26, 最終更新日: 2023-08-09)

主引用文献

Somers, W.S.,Stahl, M.L.,Sullivan, F.X.
GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
Structure, 6:1601-1612, 1998

PubMed Abstract: . In all species examined, GDP-fucose is synthesized from GDP-mannose in a three-step reaction catalyzed by two enzymes, GDP-mannose 4,6 dehydratase and a dual function 3, 5-epimerase-4-reductase named GDP-fucose synthetase. In this latter aspect fucose biosynthesis differs from that of other deoxy and dideoxy sugars, in which the epimerase and reductase activities are present as separate enzymes. Defects in GDP-fucose biosynthesis have been shown to affect nodulation in bacteria, stem development in plants, and are associated with the immune defect leukocyte adhesion deficiency type II in humans.

PubMed: 9862812
DOI: 10.1016/S0969-2126(98)00157-9

実験手法

X-RAY DIFFRACTION (2.3 Å)