1FWK

CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ADP

Summary for 1FWK

Entry DOI	10.2210/pdb1fwk/pdb
Related	1FWL
Descriptor	HOMOSERINE KINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	kinase, transferase
Biological source	Methanocaldococcus jannaschii
Cellular location	Cytoplasm : Q58504
Total number of polymer chains	4
Total formula weight	130930.59
Authors	Zhou, T.,Daugherty, M.,Grishin, N.V.,Osterman, A.L.,Zhang, H. (deposition date: 2000-09-22, release date: 2000-12-20, Last modification date: 2024-02-07)
Primary citation	Zhou, T.,Daugherty, M.,Grishin, N.V.,Osterman, A.L.,Zhang, H. Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily. Structure Fold.Des., 8:1247-1257, 2000 Cited by PubMed Abstract: Homoserine kinase (HSK) catalyzes an important step in the threonine biosynthesis pathway. It belongs to a large yet unique class of small metabolite kinases, the GHMP kinase superfamily. Members in the GHMP superfamily participate in several essential metabolic pathways, such as amino acid biosynthesis, galactose metabolism, and the mevalonate pathway. PubMed: 11188689 DOI: 10.1016/S0969-2126(00)00533-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation