1FV2

The Hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B

Summary for 1FV2

Entry DOI	10.2210/pdb1fv2/pdb
Related	1a8d 1af9 1d0h 1dfq 1diw 1dll 1fv3
Descriptor	TETANUS TOXIN HEAVY CHAIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-beta-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	toxin, carbohydrate, ganglioside, multi-valent binding, receptor
Biological source	Clostridium tetani
Total number of polymer chains	1
Total formula weight	55776.39
Authors	Fotinou, C.,Emsley, P.,Black, I.,Ando, H.,Ishida, H.,Kiso, M.,Sinha, K.A.,Fairweather, N.F.,Isaacs, N.W. (deposition date: 2000-09-18, release date: 2001-09-05, Last modification date: 2020-07-29)
Primary citation	Fotinou, C.,Emsley, P.,Black, I.,Ando, H.,Ishida, H.,Kiso, M.,Sinha, K.A.,Fairweather, N.F.,Isaacs, N.W. The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. J.Biol.Chem., 276:32274-32281, 2001 Cited by PubMed: 11418600 DOI: 10.1074/jbc.M103285200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation