1FV2

The Hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B

1FV2 の概要

• エントリーDOI: 10.2210/pdb1fv2/pdb
• 関連するPDBエントリー: 1a8d 1af9 1d0h 1dfq 1diw 1dll 1fv3
• 分子名称: TETANUS TOXIN HEAVY CHAIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-beta-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: toxin, carbohydrate, ganglioside, multi-valent binding, receptor
• 由来する生物種: Clostridium tetani
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55776.39

構造登録者

Fotinou, C.,Emsley, P.,Black, I.,Ando, H.,Ishida, H.,Kiso, M.,Sinha, K.A.,Fairweather, N.F.,Isaacs, N.W. (登録日: 2000-09-18, 公開日: 2001-09-05, 最終更新日: 2020-07-29)

• 主引用文献: Fotinou, C.,Emsley, P.,Black, I.,Ando, H.,Ishida, H.,Kiso, M.,Sinha, K.A.,Fairweather, N.F.,Isaacs, N.W.; The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.; J.Biol.Chem., 276:32274-32281, 2001; PubMed: 11418600; DOI: 10.1074/jbc.M103285200

実験手法

X-RAY DIFFRACTION (2.5 Å)