1FU7

STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN

1FU7 の概要

• エントリーDOI: 10.2210/pdb1fu7/pdb
• 関連するPDBエントリー: 1B4D 1FS4 1FTQ 1FTW 1FTY 1FU4 1FU8 1GGN
• 分子名称: GLYCOGEN PHOSPHORYLASE, N-(methoxycarbonyl)-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: transferase, glycogen phosphorylase, inhibitor complex, catalytic site, design
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97775.55

構造登録者

Watson, K.A.,Tsitsanou, K.E.,Gregoriou, M.,Zographos, S.E.,Skamnaki, V.T.,Oikonomakos, N.G.,Fleet, G.W.,Johnson, L.N. (登録日: 2000-09-14, 公開日: 2000-10-04, 最終更新日: 2023-08-09)

• 主引用文献: Watson, K.A.,Chrysina, E.D.,Tsitsanou, K.E.,Zographos, S.E.,Archontis, G.,Fleet, G.W.,Oikonomakos, N.G.; Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.; Proteins, 61:966-983, 2005; PubMed: 16222658; DOI: 10.1002/prot.20653

実験手法

X-RAY DIFFRACTION (2.36 Å)