1FQ9
CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Summary for 1FQ9
Entry DOI | 10.2210/pdb1fq9/pdb |
Related | 1CVS |
Descriptor | FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | i-set subgroup within the immunoglobulin superfamily, b-trefoil fold, growth factor-growth factor receptor complex, growth factor/growth factor receptor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 84812.58 |
Authors | Schlessinger, J.,Plotnikov, A.N.,Ibrahimi, O.A.,Eliseenkova, A.V.,Yeh, B.K.,Yayon, A.,Linhardt, R.J.,Mohammadi, M. (deposition date: 2000-09-04, release date: 2000-09-27, Last modification date: 2021-11-03) |
Primary citation | Schlessinger, J.,Plotnikov, A.N.,Ibrahimi, O.A.,Eliseenkova, A.V.,Yeh, B.K.,Yayon, A.,Linhardt, R.J.,Mohammadi, M. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol.Cell, 6:743-750, 2000 Cited by PubMed: 11030354DOI: 10.1016/S1097-2765(00)00073-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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