1FQ9

CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX

1FQ9 の概要

• エントリーDOI: 10.2210/pdb1fq9/pdb
• 関連するPDBエントリー: 1CVS
• 分子名称: FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: i-set subgroup within the immunoglobulin superfamily, b-trefoil fold, growth factor-growth factor receptor complex, growth factor/growth factor receptor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 84812.58

構造登録者

Schlessinger, J.,Plotnikov, A.N.,Ibrahimi, O.A.,Eliseenkova, A.V.,Yeh, B.K.,Yayon, A.,Linhardt, R.J.,Mohammadi, M. (登録日: 2000-09-04, 公開日: 2000-09-27, 最終更新日: 2021-11-03)

• 主引用文献: Schlessinger, J.,Plotnikov, A.N.,Ibrahimi, O.A.,Eliseenkova, A.V.,Yeh, B.K.,Yayon, A.,Linhardt, R.J.,Mohammadi, M.; Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.; Mol.Cell, 6:743-750, 2000; PubMed: 11030354; DOI: 10.1016/S1097-2765(00)00073-3

実験手法

X-RAY DIFFRACTION (3 Å)