1FNF

FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10

Summary for 1FNF

• Entry DOI: 10.2210/pdb1fnf/pdb
• Descriptor: FIBRONECTIN (2 entities in total)
• Functional Keywords: rgd, extracellular matrix, cell adhesion protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix: P02751
• Total number of polymer chains: 1
• Total formula weight: 39981.16

Authors

Leahy, D.J.,Aukhil, I.,Erickson, H.P. (deposition date: 1995-09-30, release date: 1996-01-29, Last modification date: 2024-02-07)

Primary citation

Leahy, D.J.,Aukhil, I.,Erickson, H.P.
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
Cell(Cambridge,Mass.), 84:155-164, 1996

PubMed Abstract: We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.

PubMed: 8548820
DOI: 10.1016/S0092-8674(00)81002-8

Experimental method

X-RAY DIFFRACTION (2 Å)