1FN7
COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN
Summary for 1FN7
Entry DOI | 10.2210/pdb1fn7/pdb |
Related | 1EBM |
Descriptor | DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), 8-OXOGUANINE DNA GLYCOSYLASE 1, ... (5 entities in total) |
Functional Keywords | dna repair, dna glycosylase, protein/dna, helix hairpin helix, base recognition, oxoguanine, hydroxyguanine, base flipping, flipped-out base, extrahelical dna, mechanism-based inhibitor, base-exicision repair, ap lyase, dna glycosidase, hydrolase-dna complex, hydrolase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion: O15527 |
Total number of polymer chains | 3 |
Total formula weight | 44720.23 |
Authors | Norman, D.P.G.,Bruner, S.D.,Verdine, G.L. (deposition date: 2000-08-21, release date: 2001-04-21, Last modification date: 2024-02-07) |
Primary citation | Norman, D.P.,Bruner, S.D.,Verdine, G.L. Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein. J.Am.Chem.Soc., 123:359-360, 2001 Cited by PubMed: 11456534DOI: 10.1021/ja003144m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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