1FN7

COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN

1FN7 の概要

• エントリーDOI: 10.2210/pdb1fn7/pdb
• 関連するPDBエントリー: 1EBM
• 分子名称: DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), 8-OXOGUANINE DNA GLYCOSYLASE 1, ... (5 entities in total)
• 機能のキーワード: dna repair, dna glycosylase, protein/dna, helix hairpin helix, base recognition, oxoguanine, hydroxyguanine, base flipping, flipped-out base, extrahelical dna, mechanism-based inhibitor, base-exicision repair, ap lyase, dna glycosidase, hydrolase-dna complex, hydrolase/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus, nucleoplasm. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion: O15527
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44720.23

構造登録者

Norman, D.P.G.,Bruner, S.D.,Verdine, G.L. (登録日: 2000-08-21, 公開日: 2001-04-21, 最終更新日: 2024-02-07)

• 主引用文献: Norman, D.P.,Bruner, S.D.,Verdine, G.L.; Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein.; J.Am.Chem.Soc., 123:359-360, 2001; PubMed: 11456534; DOI: 10.1021/ja003144m

実験手法

X-RAY DIFFRACTION (2.6 Å)