1FKN

Structure of Beta-Secretase Complexed with Inhibitor

Summary for 1FKN

Related PRD IDPRD_000290
DescriptorMEMAPSIN 2, inhibitor (3 entities in total)
Functional Keywordsalzheimer's disease, beta-secretase, memapsin 2, base, aspartic protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P56817
Total number of polymer chains4
Total molecular weight89040.37
Authors
Hong, L.,Koelsch, G.,Lin, X.,Wu, S.,Terzyan, S.,Ghosh, A.,Zhang, X.C.,Tang, J. (deposition date: 2000-08-09, release date: 2000-10-09, Last modification date: 2012-12-12)
Primary citation
Hong, L.,Koelsch, G.,Lin, X.,Wu, S.,Terzyan, S.,Ghosh, A.K.,Zhang, X.C.,Tang, J.
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.
Science, 290:150-153, 2000
PubMed: 11021803 (PDB entries with the same primary citation)
DOI: 10.1126/science.290.5489.150
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22380.6%3.6%5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1fkn
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Molmil generated image of 1fkn
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Molmil generated image of 1fkn
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More Biological unit images

Molmil generated image of 1fkn
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Molmil generated image of 1fkn
rotated about x axis by 90°
Molmil generated image of 1fkn
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1fkn.pdb1.gz [70.7 KB])
Coordinate files for Biological unit (1fkn.pdb2.gz [69.93 KB])