1FKH

DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12

1FKH の概要

• エントリーDOI: 10.2210/pdb1fkh/pdb
• 分子名称: FK506 BINDING PROTEIN, 1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE (3 entities in total)
• 機能のキーワード: cis-trans isomerase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytosol : P62942
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12292.14

構造登録者

Holt, D.A.,Luengo, J.I.,Yamashita, D.S.,Oh, H.-J.,Konialian, A.L.,Yen, H.-K.,Rozamus, L.W.,Brandt, M.,Bossard, M.J.,Levy, M.A.,Eggleston, D.S.,Stout, T.J.,Liang, J.,Schultz, L.W.,Clardy, J. (登録日: 1993-08-05, 公開日: 1994-01-31, 最終更新日: 2024-02-07)

• 主引用文献: Holt, D.A.,Luengo, J.I.,Yamashita, D.S.,Oh, H.J.,Konialian, A.L.,Yen, H.K.,Rozamus, L.W.,Brandt, M.,Bossard, M.J.,Levy, M.A.,Eggleston, D.S.,Liang, J.,Schultz, L.W.,Stout, T.J.,Clardy, J.; DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.; J.Am.Chem.Soc., 115:9925-9938, 1993

実験手法

X-RAY DIFFRACTION (1.95 Å)