1FKF

ATOMIC STRUCTURE OF FKBP-FK506, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX

1FKF の概要

• エントリーDOI: 10.2210/pdb1fkf/pdb
• 分子名称: FK506 BINDING PROTEIN, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN (3 entities in total)
• 機能のキーワード: isomerase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytosol : P62942
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12640.53

構造登録者

Vanduyne, G.D.,Standaert, R.F.,Karplus, P.A.,Schreiber, S.L.,Clardy, J. (登録日: 1991-05-07, 公開日: 1991-07-15, 最終更新日: 2024-02-07)

主引用文献

Van Duyne, G.D.,Standaert, R.F.,Karplus, P.A.,Schreiber, S.L.,Clardy, J.
Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.
Science, 252:839-842, 1991

PubMed Abstract: The structure of the human FK506 binding protein (FKBP), complexed with the immunosuppressant FK506, has been determined to 1.7 angstroms resolution by x-ray crystallography. The conformation of the protein changes little upon complexation, but the conformation of FK506 is markedly different in the bound and unbound forms. The drug's association with the protein involves five hydrogen bonds, a hydrophobic binding pocket lined with conserved aromatic residues, and an unusual carbonyl binding pocket. The nature of this complex has implications for the mechanism of rotamase catalysis and for the biological actions of FK506 and rapamycin.

PubMed: 1709302

実験手法

X-RAY DIFFRACTION (1.7 Å)