1FKA

STRUCTURE OF FUNCTIONALLY ACTIVATED SMALL RIBOSOMAL SUBUNIT AT 3.3 A RESOLUTION

1FKA の概要

• エントリーDOI: 10.2210/pdb1fka/pdb
• 関連するPDBエントリー: 1A32 1AN7 1C05 1EKC 1PKP 1QKF 1RIS 1RSS
• 分子名称: 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... (21 entities in total)
• 機能のキーワード: 30s ribosomal subunit, protein-rna complex, ribosome
• 由来する生物種: Thermus thermophilus; 詳細
• タンパク質・核酸の鎖数: 20
• 化学式量合計: 725011.66

構造登録者

Schluenzen, F.,Tocilj, A.,Zarivach, R.,Harms, J.,Gluehmann, M.,Janell, D.,Bashan, A.,Bartels, H.,Agmon, I.,Franceschi, F.,Yonath, A. (登録日: 2000-08-09, 公開日: 2000-09-04, 最終更新日: 2024-02-07)

主引用文献

Schluenzen, F.,Tocilj, A.,Zarivach, R.,Harms, J.,Gluehmann, M.,Janell, D.,Bashan, A.,Bartels, H.,Agmon, I.,Franceschi, F.,Yonath, A.
Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution.
Cell(Cambridge,Mass.), 102:615-623, 2000

PubMed Abstract: The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like contact closes and contributes to processivity and fidelity. Extended RNA helical elements that run longitudinally through the body transmit structural changes, correlating events at the particle's far end with the cycle of mRNA translocation at the decoding region. 96% of the nucleotides were traced and the main fold of all proteins was determined. The latter are either peripheral or appear to serve as linkers. Some may assist the directionality of translocation.

PubMed: 11007480
DOI: 10.1016/S0092-8674(00)00084-2

実験手法

X-RAY DIFFRACTION (3.3 Å)