1FJ8
THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN
Summary for 1FJ8
Entry DOI | 10.2210/pdb1fj8/pdb |
Related | 1B3N 1FJ4 |
Descriptor | BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I, (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE (3 entities in total) |
Functional Keywords | condensing enzymes, fatty acid elongation, cerulenin, drug design, transferase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P0A953 |
Total number of polymer chains | 4 |
Total formula weight | 171525.95 |
Authors | Price, A.C.,Choi, K.,Heath, R.J.,Li, Z.,White, S.W.,Rock, C.O. (deposition date: 2000-08-07, release date: 2000-08-23, Last modification date: 2011-07-13) |
Primary citation | Price, A.C.,Choi, K.H.,Heath, R.J.,Li, Z.,White, S.W.,Rock, C.O. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J.Biol.Chem., 276:6551-6559, 2001 Cited by PubMed: 11050088DOI: 10.1074/jbc.M007101200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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