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1FJ8

THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN

Summary for 1FJ8
Entry DOI10.2210/pdb1fj8/pdb
Related1B3N 1FJ4
DescriptorBETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I, (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE (3 entities in total)
Functional Keywordscondensing enzymes, fatty acid elongation, cerulenin, drug design, transferase
Biological sourceEscherichia coli
Cellular locationCytoplasm: P0A953
Total number of polymer chains4
Total formula weight171525.95
Authors
Price, A.C.,Choi, K.,Heath, R.J.,Li, Z.,White, S.W.,Rock, C.O. (deposition date: 2000-08-07, release date: 2000-08-23, Last modification date: 2011-07-13)
Primary citationPrice, A.C.,Choi, K.H.,Heath, R.J.,Li, Z.,White, S.W.,Rock, C.O.
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.
J.Biol.Chem., 276:6551-6559, 2001
Cited by
PubMed: 11050088
DOI: 10.1074/jbc.M007101200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.27 Å)
Structure validation

217705

數據於2024-03-27公開中

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