1FJ4

THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH THIOLACTOMYCIN, IMPLICATIONS FOR DRUG DESIGN

Summary for 1FJ4

• Entry DOI: 10.2210/pdb1fj4/pdb
• Related: 1B3N 1fj8
• Descriptor: BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I, THIOLACTOMYCIN (3 entities in total)
• Functional Keywords: condensing enzymes, fatty acid elongation, thiolactomycin, drug design, transferase
• Biological source: Escherichia coli
• Cellular location: Cytoplasm: P0A953
• Total number of polymer chains: 4
• Total formula weight: 171465.98

Authors

Price, A.C.,Choi, K.,Heath, R.J.,Li, Z.,White, S.W.,Rock, C.O. (deposition date: 2000-08-07, release date: 2000-08-23, Last modification date: 2024-02-07)

• Primary citation: Price, A.C.,Choi, K.H.,Heath, R.J.,Li, Z.,White, S.W.,Rock, C.O.; Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.; J.Biol.Chem., 276:6551-6559, 2001; PubMed: 11050088; DOI: 10.1074/jbc.M007101200

Experimental method

X-RAY DIFFRACTION (2.35 Å)