1FIN

CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX

1FIN の概要

• エントリーDOI: 10.2210/pdb1fin/pdb
• 分子名称: CYCLIN-DEPENDENT KINASE 2, CYCLIN A, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: complex (transferase-cyclin), cyclin, cdk, phosphorylation, complex (transferase-cyclin) complex, complex (transferase/cyclin)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P20248
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128702.36

構造登録者

Jeffrey, P.D.,Russo, A.A.,Pavletich, N.P. (登録日: 1996-07-14, 公開日: 1997-01-27, 最終更新日: 2024-02-07)

主引用文献

Jeffrey, P.D.,Russo, A.A.,Polyak, K.,Gibbs, E.,Hurwitz, J.,Massague, J.,Pavletich, N.P.
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Nature, 376:313-320, 1995

PubMed Abstract: The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes in its PSTAIRE helix and T-loop. These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.

PubMed: 7630397
DOI: 10.1038/376313a0

実験手法

X-RAY DIFFRACTION (2.3 Å)