1FIM

MACROPHAGE MIGRATION INHIBITORY FACTOR

1FIM の概要

• エントリーDOI: 10.2210/pdb1fim/pdb
• 分子名称: MACROPHAGE MIGRATION INHIBITORY FACTOR (1 entity in total)
• 機能のキーワード: macrophage, inflammatory response, cytokine
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Secreted : P30904
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12282.66

構造登録者

Suzuki, M.,Sugimoto, H.,Nakagawa, A.,Tanaka, I. (登録日: 1996-01-31, 公開日: 1996-07-11, 最終更新日: 2024-11-13)

主引用文献

Suzuki, M.,Sugimoto, H.,Nakagawa, A.,Tanaka, I.,Nishihira, J.,Sakai, M.
Crystal structure of the macrophage migration inhibitory factor from rat liver.
Nat.Struct.Biol., 3:259-266, 1996

PubMed Abstract: The tertiary structure of the macrophage migration inhibitory factor (MIF) from rat liver (12,300 Mr) is presented at 2.2 A resolution. Each monomer consists of two beta/alpha/beta motifs aligned in quasi two-fold symmetry, comprising a domain consisting of a four-stranded mixed beta-sheet and two antiparallel alpha-helices. The protein exists as a trimer in the crystal. An extra beta-strand that is almost perpendicular to the other beta-strands joins to the beta-sheet of the neighbouring monomer in the trimer. Unexpected similarities were detected between MIF and two kinds of isomerase.

PubMed: 8605628
DOI: 10.1038/nsb0396-259

実験手法

X-RAY DIFFRACTION (2.2 Å)