1FI1

FhuA in complex with lipopolysaccharide and rifamycin CGP4832

1FI1 の概要

• エントリーDOI: 10.2210/pdb1fi1/pdb
• 関連するPDBエントリー: 1QFF 1QFG 1fcp 1qjq 1qkc 2fcp
• 分子名称: FERRICHROME-IRON RECEPTOR, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-3)-[alpha-D-galactopyranose-(1-6)]alpha-D-glucopyranose-(1-3)-[L-glycero-alpha-D-manno-heptopyranose-(1-7)]L-glycero-alpha-D-manno-heptopyranose-(1-3)-L-glycero-alpha-D-manno-heptopyranose-(1-5)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2,3-dideoxy-alpha-D-glucoyranose-(1-6)-2-amino-2-deoxy-alpha-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: outer membrane protein; tonb-dependent receptor; fhua; siderophore receptor; integral membrane protein; lipopolysaccharide; rifamycin cgp 4832; beta-barrel; antibiotic, metal transport
• 由来する生物種: Escherichia coli K12
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83467.26

構造登録者

Ferguson, A.D.,Koedding, J.,Boes, C.,Walker, G.,Coulton, J.W.,Diederichs, K.,Braun, V.,Welte, W. (登録日: 2000-08-03, 公開日: 2001-08-29, 最終更新日: 2024-11-13)

主引用文献

Ferguson, A.D.,Kodding, J.,Walker, G.,Bos, C.,Coulton, J.W.,Diederichs, K.,Braun, V.,Welte, W.
Active transport of an antibiotic rifamycin derivative by the outer-membrane protein FhuA.
Structure, 9:707-716, 2001

PubMed Abstract: FhuA, an integral membrane protein of Escherichia coli, actively transports ferrichrome and the structurally related antibiotic albomycin across the outer membrane. The transport is coupled to the proton motive force, which energizes FhuA through the inner-membrane protein TonB. FhuA also transports the semisynthetic rifamycin derivative CGP 4832, although the chemical structure of this antibiotic differs markedly from that of ferric hydroxamates.

PubMed: 11587645
DOI: 10.1016/S0969-2126(01)00631-1

実験手法

X-RAY DIFFRACTION (2.9 Å)