1FG9

3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER

1FG9 の概要

• エントリーDOI: 10.2210/pdb1fg9/pdb
• 分子名称: INTERFERON GAMMA, INTERFERON-GAMMA RECEPTOR ALPHA CHAIN (2 entities in total)
• 機能のキーワード: cytokine-receptor complex, fibronectin type-iii, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01579; Membrane; Single-pass type I membrane protein: P15260
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 114410.07

構造登録者

Thiel, D.J.,le Du, M.-H.,Walter, R.L.,D'Arcy, A.,Chene, C.,Fountoulakis, M.,Garotta, G.,Winkler, F.K.,Ealick, S.E. (登録日: 2000-07-28, 公開日: 2000-08-11, 最終更新日: 2024-10-30)

主引用文献

Thiel, D.J.,le Du, M.H.,Walter, R.L.,D'Arcy, A.,Chene, C.,Fountoulakis, M.,Garotta, G.,Winkler, F.K.,Ealick, S.E.
Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.
Structure Fold.Des., 8:927-936, 2000

PubMed Abstract: Molecular interactions among cytokines and cytokine receptors form the basis of many cell-signaling pathways relevant to immune function. Interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species-specific accessory factor (AF-1 or IFN-gammaRbeta). In the signaling complex, the two receptors probably interact with one another through their extracellular domains. Understanding the atomic interactions of signaling complexes enhances the ability to control and alter cell signaling and also provides a greater understanding of basic biochemical processes.

PubMed: 10986460
DOI: 10.1016/S0969-2126(00)00184-2

実験手法

X-RAY DIFFRACTION (2.9 Å)