1FDT

HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRADIOL AND NADP+

1FDT の概要

• エントリーDOI: 10.2210/pdb1fdt/pdb
• 分子名称: 17-BETA-HYDROXYSTEROID-DEHYDROGENASE, SULFATE ION, ESTRADIOL, ... (5 entities in total)
• 機能のキーワード: dehydrogenase, 17-beta-hydroxysteroid
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14061
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36085.79

構造登録者

Housset, D.,Breton, R.,Mazza, C.,Fontecilla-Camps, J.-C. (登録日: 1996-06-28, 公開日: 1997-02-12, 最終更新日: 2024-12-25)

主引用文献

Breton, R.,Housset, D.,Mazza, C.,Fontecilla-Camps, J.C.
The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.
Structure, 4:905-915, 1996

PubMed Abstract: The steroid hormone 17beta-estradiol is important in the genesis and development of human breast cancer. Its intracellular concentration is regulated by 17beta-hydroxysteroid dehydrogenase, which catalyzes the reversible reduction of estrone to 17beta-estradiol. This enzyme is thus an important target for inhibitor design. The precise localization and orientation of the substrate and cofactor in the active site is of paramount importance for the design of such inhibitors, and for an understanding of the catalytic mechanism.

PubMed: 8805577
DOI: 10.1016/S0969-2126(96)00098-6

実験手法

X-RAY DIFFRACTION (2.2 Å)