1FDG

BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (AMETANTRONE COMPLEX)

Summary for 1FDG

• Entry DOI: 10.2210/pdb1fdg/pdb
• Related: 1FD5
• Descriptor: DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), COBALT (II) ION, 1,4-BIS-[2-(2-HYDROXY-ETHYLAMINO)-ETHYLAMINO]-ANTHRAQUINONE, ... (5 entities in total)
• Functional Keywords: high resolution crystal structure, intercalation platform, mad, anticancer drug, drug-dna complex, metal ions, tertiary base pairs, dna
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 3968.82

Authors

Yang, X.-L.,Robinson, H.,Gao, Y.-G.,Wang, A.H.-J. (deposition date: 2000-07-20, release date: 2000-08-07, Last modification date: 2022-09-14)

• Primary citation: Yang, X.L.,Robinson, H.,Gao, Y.G.,Wang, A.H.; Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.; Biochemistry, 39:10950-10957, 2000; PubMed: 10998231; DOI: 10.1021/bi001319z

Experimental method

X-RAY DIFFRACTION (1.6 Å)