1FCG

ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA

1FCG の概要

• エントリーDOI: 10.2210/pdb1fcg/pdb
• 分子名称: PROTEIN (FC RECEPTOR FC(GAMMA)RIIA) (2 entities in total)
• 機能のキーワード: fc receptor, immunogloulin, leukocyte, cd32, immune system, membrane protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P12318
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19556.86

構造登録者

Maxwell, K.F.,Powell, M.S.,Garrett, T.P.,Hogarth, P.M. (登録日: 1999-04-07, 公開日: 2000-04-12, 最終更新日: 2024-10-16)

主引用文献

Maxwell, K.F.,Powell, M.S.,Hulett, M.D.,Barton, P.A.,McKenzie, I.F.,Garrett, T.P.,Hogarth, P.M.
Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa.
Nat.Struct.Biol., 6:437-442, 1999

PubMed Abstract: Fc gamma receptors bind IgG to initiate cellular responses against pathogens and soluble antigens. We have determined the three-dimensional structure of the extracellular portion of human Fc gammaRIIa to 2.0 A resolution providing a structural basis for the unique functions of the leukocyte FcR family. The receptor is composed of two immunoglobulin domains and arranged to expose the ligand-binding site at one end of domain 2. Using alanine mutants we find that the binding sites for IgG1 and 2 are similar but the relative importance of specific regions on the receptor varies. In crystals, Fc gammaRIIa molecules associate to resemble V(L)V(H) dimers, suggesting that two Fc gammaRIIa molecules could cooperate to bind IgG in an asymmetric manner.

PubMed: 10331870
DOI: 10.1038/8241

実験手法

X-RAY DIFFRACTION (2 Å)