1FB7
CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE
Summary for 1FB7
Entry DOI | 10.2210/pdb1fb7/pdb |
Related PRD ID | PRD_000454 |
Descriptor | HIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total) |
Functional Keywords | hiv protease, mutant, drug resistance, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 1 |
Total formula weight | 11520.69 |
Authors | Hong, L.,Zhang, X.C.,Hartsuck, J.A.,Tang, J. (deposition date: 2000-07-14, release date: 2000-12-13, Last modification date: 2024-02-07) |
Primary citation | Hong, L.,Zhang, X.C.,Hartsuck, J.A.,Tang, J. Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance. Protein Sci., 9:1898-1904, 2000 Cited by PubMed: 11106162PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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