1F8X

CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE

1F8X の概要

• エントリーDOI: 10.2210/pdb1f8x/pdb
• 分子名称: NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE (2 entities in total)
• 機能のキーワード: active site, alpha/beta protein, biocatalyst, nucleoside, transferase
• 由来する生物種: Lactobacillus leichmannii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36196.71

構造登録者

Armstrong, S.R.,Cook, W.J.,Short, S.A.,Ealick, S.E. (登録日: 2000-07-05, 公開日: 2000-07-26, 最終更新日: 2024-02-07)

主引用文献

Armstrong, S.R.,Cook, W.J.,Short, S.A.,Ealick, S.E.
Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site.
Structure, 4:97-107, 1996

PubMed Abstract: Nucleoside 2-deoxyribosyltransferase plays an important role in the salvage pathway of nucleotide metabolism in certain organisms, catalyzing the cleavage of beta-2'-deoxyribonucleosides and the subsequent transfer of the deoxyribosyl moiety to an acceptor purine or pyrimidine base. The kinetics describe a ping-pong-bi-bi pathway involving the formation of a covalent enzyme-deoxyribose intermediate. The enzyme is produced by a limited number of microorganisms and its functions have been exploited in its use as a biocatalyst to synthesize nucleoside analogs of therapeutic interest.

PubMed: 8805514
DOI: 10.1016/S0969-2126(96)00013-5

実験手法

X-RAY DIFFRACTION (2.5 Å)