1F8T

FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE

Summary for 1F8T

• Entry DOI: 10.2210/pdb1f8t/pdb
• Descriptor: ANTIBODY FAB FRAGMENT (LIGHT CHAIN), ANTIBODY FAB FRAGMENT (HEAVY CHAIN) (3 entities in total)
• Functional Keywords: monoclonal antibody, antigen-binding fragment, interleukin-2, x-ray analysis, crystal, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 48057.51

Authors

Fokin, A.V.,Afonin, P.V.,Mikhailova, I.I.,Tsygannik, I.N.,Mareeva, T.I. (deposition date: 2000-07-05, release date: 2001-07-05, Last modification date: 2018-04-04)

Primary citation

Fokin, A.V.,Afonin, P.V.,Mikhailova, I.I.u.,Tsygannik, I.N.,Mareeva, T.I.u.,Nesmeianov, V.A.,Pangborn, W.,Lee, N.,Duax, W.,Siszak, E.,Pletnev, V.Z.
Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms
Bioorg.Khim., 26:571-578, 2000

PubMed Abstract: The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.

PubMed: 11040993

Experimental method

X-RAY DIFFRACTION (2.2 Å)