1F80

HOLO-(ACYL CARRIER PROTEIN) SYNTHASE IN COMPLEX WITH HOLO-(ACYL CARRIER PROTEIN)

1F80 の概要

• エントリーDOI: 10.2210/pdb1f80/pdb
• 関連するPDBエントリー: 1F7L 1F7T
• 分子名称: HOLO-(ACYL CARRIER PROTEIN) SYNTHASE, ACYL CARRIER PROTEIN, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: 9-strand pseudo beta barrel holo-(acyl carrier protein) acp holo-(acyl carrier protein) synthase acps, transferase
• 由来する生物種: Bacillus subtilis; 詳細
• 細胞内の位置: Cytoplasm : P96618 P80643
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 68148.26

構造登録者

Parris, K.D.,Lin, L.,Tam, A.,Mathew, R.,Hixon, J.,Stahl, M.,Fritz, C.C.,Seehra, J.,Somers, W.S. (登録日: 2000-06-28, 公開日: 2001-06-28, 最終更新日: 2023-08-09)

主引用文献

Parris, K.D.,Lin, L.,Tam, A.,Mathew, R.,Hixon, J.,Stahl, M.,Fritz, C.C.,Seehra, J.,Somers, W.S.
Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites.
Structure Fold.Des., 8:883-895, 2000

PubMed Abstract: Holo-(acyl carrier protein) synthase (AcpS), a member of the phosphopantetheinyl transferase superfamily, plays a crucial role in the functional activation of acyl carrier protein (ACP) in the fatty acid biosynthesis pathway. AcpS catalyzes the attachment of the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to the sidechain of a conserved serine residue on apo-ACP.

PubMed: 10997907
DOI: 10.1016/S0969-2126(00)00178-7

実験手法

X-RAY DIFFRACTION (2.3 Å)