1F4S

STRUCTURE OF TRANSCRIPTIONAL FACTOR ALCR IN COMPLEX WITH A TARGET DNA

Summary for 1F4S

• Entry DOI: 10.2210/pdb1f4s/pdb
• Related: 2ALC 3ALC
• Descriptor: DNA (5'-D(P*CP*GP*TP*GP*CP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*GP*CP*AP*CP*G)-3'), ETHANOL REGULON TRANSCRIPTIONAL FACTOR, ... (5 entities in total)
• Functional Keywords: protein-dna complex, zinc binuclear cluster protein, transcription-dna complex, transcription/dna
• Biological source: Emericella nidulans
• Cellular location: Nucleus: P21228
• Total number of polymer chains: 3
• Total formula weight: 13802.16

Authors

Cahuzac, B.,Cerdan, R.,Felenbok, B.,Guittet, E. (deposition date: 2000-06-09, release date: 2001-09-28, Last modification date: 2024-05-22)

Primary citation

Cahuzac, B.,Cerdan, R.,Felenbok, B.,Guittet, E.
The solution structure of an AlcR-DNA complex sheds light onto the unique tight and monomeric DNA binding of a Zn(2)Cys(6) protein.
Structure, 9:827-836, 2001

PubMed Abstract: In Aspergillus nidulans, the transcription activator AlcR mediates specific induction of a number of the genes of the alc cluster. This cluster includes genes involved in the oxidation of ethanol and other alcohols to acetate. The pattern of binding and of transactivation of AlcR is unique within the Zn(2)Cys(6) family. The structural bases for these specificities have not been analyzed at the atomic level until now.

PubMed: 11566132
DOI: 10.1016/S0969-2126(01)00640-2

Experimental method

SOLUTION NMR