1F4S

STRUCTURE OF TRANSCRIPTIONAL FACTOR ALCR IN COMPLEX WITH A TARGET DNA

1F4S の概要

• エントリーDOI: 10.2210/pdb1f4s/pdb
• 関連するPDBエントリー: 2ALC 3ALC
• 分子名称: DNA (5'-D(P*CP*GP*TP*GP*CP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*GP*CP*AP*CP*G)-3'), ETHANOL REGULON TRANSCRIPTIONAL FACTOR, ... (5 entities in total)
• 機能のキーワード: protein-dna complex, zinc binuclear cluster protein, transcription-dna complex, transcription/dna
• 由来する生物種: Emericella nidulans
• 細胞内の位置: Nucleus: P21228
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 13802.16

構造登録者

Cahuzac, B.,Cerdan, R.,Felenbok, B.,Guittet, E. (登録日: 2000-06-09, 公開日: 2001-09-28, 最終更新日: 2024-05-22)

主引用文献

Cahuzac, B.,Cerdan, R.,Felenbok, B.,Guittet, E.
The solution structure of an AlcR-DNA complex sheds light onto the unique tight and monomeric DNA binding of a Zn(2)Cys(6) protein.
Structure, 9:827-836, 2001

PubMed Abstract: In Aspergillus nidulans, the transcription activator AlcR mediates specific induction of a number of the genes of the alc cluster. This cluster includes genes involved in the oxidation of ethanol and other alcohols to acetate. The pattern of binding and of transactivation of AlcR is unique within the Zn(2)Cys(6) family. The structural bases for these specificities have not been analyzed at the atomic level until now.

PubMed: 11566132
DOI: 10.1016/S0969-2126(01)00640-2

実験手法

SOLUTION NMR