1F2V

CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE OF AEROBIC VITAMIN B12 SYNTHESIS

1F2V の概要

• エントリーDOI: 10.2210/pdb1f2v/pdb
• 分子名称: PRECORRIN-8X METHYLMUTASE (2 entities in total)
• 機能のキーワード: alpha-beta wind, doubly wound sheet, isomerase
• 由来する生物種: Pseudomonas denitrificans
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23217.51

構造登録者

Shipman, L.W.,Li, D.,Roessner, C.A.,Scott, A.I.,Sacchettini, J.C. (登録日: 2000-05-29, 公開日: 2001-07-18, 最終更新日: 2024-02-07)

主引用文献

Shipman, L.W.,Li, D.,Roessner, C.A.,Scott, A.I.,Sacchettini, J.C.
Crystal structure of precorrin-8x methyl mutase.
Structure, 9:587-596, 2001

PubMed Abstract: The crystal structure of precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12, provides evidence that the mechanism for methyl migration can plausibly be regarded as an allowed [1,5]-sigmatropic shift of a methyl group from C-11 to C-12 at the C ring of precorrin-8x to afford hydrogenobyrinic acid.

PubMed: 11470433
DOI: 10.1016/S0969-2126(01)00618-9

実験手法

X-RAY DIFFRACTION (2.1 Å)