1F2A

CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (II)

1F2A の概要

• エントリーDOI: 10.2210/pdb1f2a/pdb
• 関連するPDBエントリー: 1AIM 1EWL 1EWM 1EWO 1EWP 1F29 1F2B 1F2C 2AIM
• 分子名称: CRUZAIN, 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONYLMETHYLBENZENE (3 entities in total)
• 機能のキーワード: cysteine protease, covalent inhibitor, vinyl sulfone derived, p1' pocket, hydrolase
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23313.89

構造登録者

Brinen, L.S.,Hansell, E.,Roush, W.R.,McKerrow, J.H.,Fletterick, R.J. (登録日: 2000-05-23, 公開日: 2000-07-26, 最終更新日: 2024-11-06)

主引用文献

Brinen, L.S.,Hansell, E.,Cheng, J.,Roush, W.R.,McKerrow, J.H.,Fletterick, R.J.
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure Fold.Des., 8:831-840, 2000

PubMed Abstract: Cysteine proteases of the papain superfamily are present in nearly all groups of eukaryotes and play vital roles in a wide range of biological processes and diseases, including antigen and hormone processing, bacterial infection, arthritis, osteoporosis, Alzheimer's disease and cancer-cell invasion. Because they are critical to the life-cycle progression of many pathogenic protozoa, they represent potential targets for selective inhibitors. Chagas' disease, the leading cause of death due to heart disease in Latin American countries, is transmitted by Trypanosoma cruzi. Cruzain is the major cysteine protease of T cruzi and has been the target of extensive structure-based drug design.

PubMed: 10997902
DOI: 10.1016/S0969-2126(00)00173-8

実験手法

X-RAY DIFFRACTION (1.6 Å)