1F05

CRYSTAL STRUCTURE OF HUMAN TRANSALDOLASE

1F05 の概要

• エントリーDOI: 10.2210/pdb1f05/pdb
• 関連するPDBエントリー: 1ONR 1UCW
• 分子名称: TRANSALDOLASE (2 entities in total)
• 機能のキーワード: alpha-beta barrel, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P37837
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75182.21

構造登録者

Schneider, G.,Thorell, S. (登録日: 2000-05-14, 公開日: 2000-07-13, 最終更新日: 2023-08-09)

主引用文献

Thorell, S.,Gergely Jr., P.,Banki, K.,Perl, A.,Schneider, G.
The three-dimensional structure of human transaldolase.
FEBS Lett., 475:205-208, 2000

PubMed Abstract: The crystal structure of human transaldolase has been determined to 2.45 A resolution. The enzyme folds into an alpha/beta barrel structure and is thus similar in structure to other class I aldolases. Structure-based sequence alignment of available sequences of the transaldolase subfamily reveals that eight active site residues are invariant in the whole subfamily. Other invariant residues are mainly involved in the formation of the hydrophobic core of the enzyme. Noteworthy is a hydrophobic cluster consisting of five invariant residues. Human transaldolase has been implicated as an autoantigen in multiple sclerosis and four immunodominant peptide segments are located at the surface of the enzyme, accessible to autoantibodies.

PubMed: 10869557
DOI: 10.1016/S0014-5793(00)01658-6

実験手法

X-RAY DIFFRACTION (2.45 Å)