1EVZ

CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH NAD

1EVZ の概要

• エントリーDOI: 10.2210/pdb1evz/pdb
• 関連するPDBエントリー: 1EVY
• 分子名称: GLYCEROL-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PENTADECANE, ... (4 entities in total)
• 機能のキーワード: dehydrogenase, rossmann fold, oxidoreductase
• 由来する生物種: Leishmania mexicana
• 細胞内の位置: Glycosome: P90551
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40193.67

構造登録者

Suresh, S.,Turley, S.,Opperdoes, F.R.,Michels, P.A.M.,Hol, W.G.J. (登録日: 2000-04-21, 公開日: 2001-02-22, 最終更新日: 2024-02-07)

主引用文献

Suresh, S.,Turley, S.,Opperdoes, F.R.,Michels, P.A.,Hol, W.G.
A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Structure Fold.Des., 8:541-552, 2000

PubMed Abstract: NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. Although the enzyme has been characterized and cloned from a number of sources, until now no three-dimensional structure has been determined for this enzyme. Although the utility of this enzyme as a drug target against Leishmania mexicana is yet to be established, the critical role played by GPDH in the long slender bloodstream form of the related kinetoplastid Trypanosoma brucei makes it a viable drug target against sleeping sickness.

PubMed: 10801498
DOI: 10.1016/S0969-2126(00)00135-0

実験手法

X-RAY DIFFRACTION (2.8 Å)