1EVE

THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE

1EVE の概要

• エントリーDOI: 10.2210/pdb1eve/pdb
• 分子名称: ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: alzheimer's disease, drug, serine hydrolase, alpha/beta hydrolase, neurotransmitter cleavage, catalytic triad, glycosylated protein
• 由来する生物種: Torpedo californica (Pacific electric ray)
• 細胞内の位置: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62792.61

構造登録者

Kryger, G.,Silman, I.,Sussman, J.L. (登録日: 1998-03-04, 公開日: 1999-01-20, 最終更新日: 2023-08-09)

• 主引用文献: Kryger, G.,Silman, I.,Sussman, J.L.; Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.; Structure Fold.Des., 7:297-307, 1999; PubMed: 10368299; DOI: 10.1016/S0969-2126(99)80040-9

実験手法

X-RAY DIFFRACTION (2.5 Å)