1EVE
THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE
1EVE の概要
エントリーDOI | 10.2210/pdb1eve/pdb |
分子名称 | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
機能のキーワード | alzheimer's disease, drug, serine hydrolase, alpha/beta hydrolase, neurotransmitter cleavage, catalytic triad, glycosylated protein |
由来する生物種 | Torpedo californica (Pacific electric ray) |
細胞内の位置 | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 62792.61 |
構造登録者 | |
主引用文献 | Kryger, G.,Silman, I.,Sussman, J.L. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure Fold.Des., 7:297-307, 1999 Cited by PubMed: 10368299DOI: 10.1016/S0969-2126(99)80040-9 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.5 Å) |
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