1EUS

SIALIDASE COMPLEXED WITH 2-DEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID

1EUS の概要

• エントリーDOI: 10.2210/pdb1eus/pdb
• 分子名称: SIALIDASE, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID (3 entities in total)
• 機能のキーワード: neuraminidase, sialidase, hydrolase
• 由来する生物種: Micromonospora viridifaciens
• 細胞内の位置: Secreted: Q02834
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39183.96

構造登録者

Gaskell, A.,Crennell, S.J.,Taylor, G.L. (登録日: 1996-06-21, 公開日: 1997-01-11, 最終更新日: 2024-02-07)

主引用文献

Gaskell, A.,Crennell, S.,Taylor, G.
The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll.
Structure, 3:1197-1205, 1995

PubMed Abstract: Sialidases, or neuraminidases, have been implicated in the pathogenesis of many diseases, but are also produced by many non-pathogenic bacteria. Bacterial sialidases are very variable in size, often possessing domains in addition to the catalytic domain. The sialidase from the non-pathogenic soil bacterium Micromonospora viridifaciens is secreted in two forms with molecular weights of 41 kDa or 68 kDa, depending on the nature of the carbohydrate used to induce expression.

PubMed: 8591030
DOI: 10.1016/S0969-2126(01)00255-6

実験手法

X-RAY DIFFRACTION (2 Å)