1ETZ

THE THREE-DIMENSIONAL STRUCTURE OF AN ANTI-SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS

Summary for 1ETZ

• Entry DOI: 10.2210/pdb1etz/pdb
• Related: 1CGS 2CGR
• Descriptor: FAB NC10.14 - LIGHT CHAIN, FAB NC10.14 - HEAVY CHAIN, N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID, ... (4 entities in total)
• Functional Keywords: anti-sweetener fab, antigen-antibody, complex, receptor mimicry, antigen recognition, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 4
• Total formula weight: 96036.59

Authors

Guddat, L.W.,Shan, L.,Broomell, C.,Ramsland, P.A.,Fan, Z.,Anchin, J.M.,Linthicum, D.S.,Edmundson, A.B. (deposition date: 2000-04-13, release date: 2000-10-18, Last modification date: 2017-10-04)

• Primary citation: Guddat, L.W.,Shan, L.,Broomell, C.,Ramsland, P.A.,Fan, Z.,Anchin, J.M.,Linthicum, D.S.,Edmundson, A.B.; The three-dimensional structure of a complex of a murine Fab (NC10. 14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins.; J.Mol.Biol., 302:853-872, 2000; PubMed: 10993728; DOI: 10.1006/jmbi.2000.4083

Experimental method

X-RAY DIFFRACTION (2.6 Å)