1ETS

REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS

1ETS の概要

• エントリーDOI: 10.2210/pdb1ets/pdb
• 関連するPDBエントリー: 1ETR 1ETT
• 関連するBIRD辞書のPRD_ID: PRD_000451
• 分子名称: EPSILON-THROMBIN, 1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, ... (4 entities in total)
• 機能のキーワード: serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bos taurus (cow); 詳細
• 細胞内の位置: Secreted, extracellular space: P00735 P00735
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36029.29

構造登録者

Bode, W.,Brandstetter, H. (登録日: 1992-07-06, 公開日: 1994-01-31, 最終更新日: 2012-12-12)

• 主引用文献: Brandstetter, H.,Turk, D.,Hoeffken, H.W.,Grosse, D.,Sturzebecher, J.,Martin, P.D.,Edwards, B.F.,Bode, W.; Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.; J.Mol.Biol., 226:1085-1099, 1992; PubMed: 1518046; DOI: 10.1016/0022-2836(92)91054-S

実験手法

X-RAY DIFFRACTION (2.3 Å)