1ETR
REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS
Summary for 1ETR
Entry DOI | 10.2210/pdb1etr/pdb |
Related | 1ETS 1ETT |
Related PRD ID | PRD_000452 |
Descriptor | EPSILON-THROMBIN, amino{[(4S)-5-[(2R,4R)-2-carboxy-4-methylpiperidin-1-yl]-4-({[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}amino)-5-oxopentyl]amino}methaniminium, ... (4 entities in total) |
Functional Keywords | serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bos taurus (cow) More |
Cellular location | Secreted, extracellular space: P00735 P00735 |
Total number of polymer chains | 2 |
Total formula weight | 36017.30 |
Authors | Bode, W.,Brandstetter, H. (deposition date: 1992-07-06, release date: 1994-01-31, Last modification date: 2024-06-05) |
Primary citation | Brandstetter, H.,Turk, D.,Hoeffken, H.W.,Grosse, D.,Sturzebecher, J.,Martin, P.D.,Edwards, B.F.,Bode, W. Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J.Mol.Biol., 226:1085-1099, 1992 Cited by PubMed: 1518046DOI: 10.1016/0022-2836(92)91054-S PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report