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1ERO

X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID

Summary for 1ERO
Entry DOI10.2210/pdb1ero/pdb
Related1ERM 1ERQ
NMR InformationBMRB: 6024,6357
DescriptorTEM-1 BETA-LACTAMASE, (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID (3 entities in total)
Functional Keywordsbeta-lactamase, structure-based design, boronate inhibitor, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight29269.13
Authors
Ness, S.,Martin, R.,Kindler, A.M.,Paetzel, M.,Gold, M.,Jones, J.B.,Strynadka, N.C.J. (deposition date: 2000-04-06, release date: 2000-05-10, Last modification date: 2011-07-13)
Primary citationNess, S.,Martin, R.,Kindler, A.M.,Paetzel, M.,Gold, M.,Jensen, S.E.,Jones, J.B.,Strynadka, N.C.
Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Biochemistry, 39:5312-5321, 2000
Cited by
PubMed: 10820001
DOI: 10.1021/bi992505b
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

数据于2024-03-27公开中

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